Integrative analysis of the lncRNA-miRNA-mRNA interactions in smooth muscle cell phenotypic transitions
Objectives: We previously found that the pluripotency factor OCT4 is reactivated in smooth muscle cells (SMC) in human and mouse atherosclerotic plaques and plays an atheroprotective role.Loss of OCT4 in SMC in vitro was associated with decreases in SMC migration.However, molecular mechanisms responsible for atheroprotective SMC-OCT4-dependent effe